Introduction
Genomics is the study of human genes and chromosomes. There are 24,000 genes and 23 pairs of chromosomes in the human genome. It is an interdisciplinary field of biology which mainly focuses on structure, organization, evolution, mapping and editing of genomes. Genomics refers to the study of all the genes involved at the proteome, metabolomics, and transcriptome levels. It’s an organism’s complete set of DNA, comprising all of its genes as well as its hierarchical, 3-D structural configuration.
There are Different Types of Genomics Such As
Chylous ascites is defined as the milky appearance that results from leakage of lipid rich lymph into the peritoneal cavity. This usually occurs due to trauma and increased peritoneal lymphatic pressure or rupture of the lymphatics. Presence of the ascitic fluid with high fat (triglyceride), usually more than 200 mg/dL is defined as true chylous ascites.
- Structural genomics: It helps to identify the structure of each protein that the genome encodes.
- Functional genomics: It aims to gather and use data from sequencing to describe the roles of genes and proteins.
- Comparative genomics: It compares the genetic characteristics of several species.
- Mutation genomics: It studies a person’s genome or DNA in terms of mutations that take place there.
The phenotypic variety of health and disease is influenced by the interaction of genetic networks and environmental variables. Ayurgenomics, which combines genomics with Ayurveda and has revealed new information on the tridosha that may open the door for therapeutic approach. According to the Ayurvedic Tridosha hypothesis, each person’s physiology is controlled by three basic principles or forces known as doshas. Each person is born with a combination of these three doshas; this is referred to as Prakriti. Every individual has their unique genetic makeup, or Prakriti.
According to their prikriti, disease evaluation, as well as the choice of a preventive and therapeutic regimen, is based on each person’s unique phenotypic characteristics. The dosha known as vata is responsible for all bodily transportation, including the movement of molecules and electrical impulses [2]. It comes from the ether and air elements. Pitta is the dosha that controls all internal metabolic processes in each cell, including the process of digestion. Fire and water combine to create it. The dosha known as kapha is in charge of the body’s coherence and structure. It is a manifestation of both water and earth. Prakriti can be divided into seven categories: Vata; Pitta; Kapha; Vata/Pitta; Pitta/Kapha; Vata/Kapha; and Vata/Pitta/Kapha. Prakriti describes a person’s behavioral traits, which are predetermined at birth and cannot be completely changed while a person is alive. Three Prakriti aspects—aushadhi (medication), vihara (lifestyle), and ahara (diet)- are the foundation of ayurvedic techniques.
These Ayurvedic traits can be used to establish a foundation for Prakriti-based medicine, preventative medicine, and improvement of life quality with longevity. Genomic research revealed that the primary Prakriti types’ gene expression levels varied greatly, notably those associated in immunity, cell division, blood coagulation, and other processes. Genomic research and Ayurveda can complement one another, particularly in the area of preventive healthcare. It is especially relevant to P4 medicine, which draws on some basic ayurvedic principles and is predictive, preventive, personalized, and participatory. A person’s Prakriti can give a good idea of their physical ability and constraints, mental tendencies, and susceptibility to a variety of ailments [3].
Epigenetics in Ayurveda
Epigenetics is the study that focuses on determining how changes in the environment and behavior affect how genes operate. As epigenetics combines genotypic and phenotypic changes, it is thought that epigenetics is a crucial aspect of Ayurveda. The factors that affect the Deha (body) Prakriti (psychological and physiological composition), which relates to the phenotype, as well as the Janma (birth) Prakriti, which relates to the genotype, are discussed in Ayurveda.
These factors include behavior, lifestyle, stress, diet, and digestion, as well as the environment. Prakriti, which is fixed at birth, doesn’t change during the course of a person’s life. This can include an appropriate way of classifying phenotypes for genotyping and is independent of ethnic, racial, or geographic characteristics. Rasapanchaka (ayurvedic pharmacology), which denotes that a drug’s activity is related to positive drug attributes like Prabhava (effect), Guna (property), Virya (potency), Rasa (taste), and Vipaka (post-digestive taste), whereas modern pharmacology denotes that a drug’s activity is based on molecular chemical. Both prakriti-oriented medicine and personalized medicine place a strong emphasis on the value of improving health and treating illnesses. The field of epigenomics investigates how proteins, metabolic processes, genetic and non-genetic factors, and variations in pathways affect human physiology and a person’s susceptibility for disease.
Cross kingdom genomics
By modifying or controlling the expression of genetic activity depending on their human genetic make-up, current science is able to comprehend the balance between a healthy lifestyle and disease. Diseases linked to lifestyle are the root of humanity’s problems, and ayurveda can treat many of these issues by promoting a healthy lifestyle and minimizing the negative effects of chronic illnesses. Ayurgenomics offers a genetic explanation and expression for how phytochemicals alter the equilibrium between human health and illnesses. Since ancient times, people have believed that plants can be used as medicines because they have less toxicity and adverse effects than synthetic pharmaceuticals, and because phytochemical compounds support complicated physiological mechanisms.
Conclusion
Many studies in both clinical and scientific settings have demonstrated the positive effects of Holy basil phytochemicals. Tulsi has a variety of health benefits, including antibacterial, antiviral, cancer-fighting, anti-cancer, anti-diabetic, antioxidant, anti-inflammatory, and antifertility qualities. By separating RNA and DNA investigations using “Next Generation Sequencing,” it is possible to demonstrate a strong association between Prikriti and to determine the genomic signature. In conclusion, cross-kingdom regulation appears as key to resolving the unavoidable question of how these medicinal plants influence the human transcriptome. The finding of these novel pathways could significantly advance our understanding of molecular signaling between species.
Author Bio
Dr. Vikram Chauhan (MD – Ayurveda) is the CEO and Founder of Planet Ayurveda Pvt. Ltd. He is Author of the Book “Ayurveda – God’s Manual For Healing”. He is an Ayurveda Expert Serving People worldwide through all the Possible Mediums, Operating from Main Branch in Mohali, India. With his Vast Experience in Herbs and their Applied Uses, he is successfully treating Numerous Patients suffering from Various Ailments. He is Serving the Society with Purest Herbal Supplements for One and only Purpose of Making People know and utilize the Wonderful Benefits of the Ayurvedic Diet, Lifestyle, and Natural Herbs. He Formulates Herbal Supplements himself and also Use Classical Ayurvedic Formulations for Helping People Get Rid of All Types of Health Issues, Restore their Health, Uses and Save themselves from the Worst Side-effects of Chemical Based Treatments. For More Details, visit www.PlanetAyurveda.com.